Treatment of delusions in dementia with Lewy bodies - response to pharmacotherapy.

BACKGROUND Delusions are clinically important symptoms in dementia with Lewy bodies (DLB). The purpose of this review is to examine the level of evidence for treatment of delusions in DLB. METHODS To achieve this objective Medline was searched. Studies were included in the review if they were prospective, separated delusions from hallucinations and were tested in patients with DLB. RESULTS The review yielded a total of six studies. Although all studies showed effectiveness, only one study using rivastigmine had an adequate patient sample size and used a randomized controlled design. CONCLUSION Further studies are required before a definitive conclusion can be reached about effective treatments.